Kashif Adil Ahmad
- Associate Professor
- College of Chiropractic
- Associate Director
- Office of Faculty Development
Office Phone:952-888-4777 ext. 330
Currently Teaching (2014-2015)
- BIOLOGY TODAY
- FUNDAMENTAL PRINCIPLES OF NUTRITION
- PATHOLOGY 1
- PATHOLOGY 2
- PHYSIOLOGY 2
Current Research Interests
Mechanism(s) of apoptosis in cancer cells:
- Induction of apoptosis in cancer cells, with special emphasis on protein kinase CK2 signaling
- Crosstalk between mitochondria, caspases and CK2
- Targeting kinase signal in cancer cells
- Investigation of novel bio-active molecules or potential candidates with anti-tumor activity
Intra-cellular redox status and free radical damage:
To investigate the role of reactive oxygen species (ROS) in tumor cell death. To elucidate free radical damage and mechanism(s) of ROS producing drugs such as resveratrol, EGCG and other related phenolic compounds.
The “learning process” includes the attainment of knowledge as well as the acquisition of skills. The “teaching process” is the method for promoting learning. One who masters this art is a teacher.
I have taught a variety of health and life science subjects including physiology, nutrition, biology, pharmacology, pathology and dermatology. With a degree in medicine and a PhD, I have more than 12 years of teaching experience in Singapore, the United Kingdom and the United States. Despite being an avid basic scientist, I value teaching and enjoy interacting with my students and peers at Northwestern.
To quote a line from the movie Spiderman, “With great powers comes great responsibility.” I feel that teachers hold great power and I take that responsibility quite seriously.
- Bachelor of Medicine and Bachelor of Surgery - University of Karachi - Pakistan, 1996
- Master of Science - University of London, 1998
- Doctor of Philosophy - National University of Singapore, 2005
- Master of Science in Medical Education Leadership - University of New England, 2011
Kavandi L, Lee LR, Bokhari AA, Pirog JE, Jiang Y, Ahmad KA, Syed V. The Chinese herbs Scutellaria baicalensis and Fritillaria cirrhosa target NFκB to inhibit proliferation of ovarian and endometrial cancer cells. Mol Carcinog. 2013 Nov 19; doi: 10.1002/mc.22107. [Epub ahead of print].
Trembly, JH, Unger, GM, Tobolt, DK, Lorman, VL, Wang, G, Ahmad, KA, Slaton, JW, Kren, BT, Ahmed, K. Systemic administration of antisense oligonucleotides CK2 α and α’ and subunits reduces orthotopic xenograft prostate tumors in mice. Mol Cell Biochem. 2011;356:21-35.
Hanif I, Hanif I, Shazib A, Ahmad KA, Pervaiz S. Casein kinase II: an attractive target for anti-cancer drug design. Int J Biochem and Cell Biol. 2010;42(10):1602-1605.
Wang G, Pan Y, Ahmad KA, Ahmed K. Protein B23/nucleophosphamin/numatrin dynamics in relation to protein kinase CK2 and apoptotic activity in cancer cells. Biochemistry. 2010;49(18):3842-3852.
Hanif I, Ahmad KA, Ahmed K, Pervaiz S. Involvement of ROS in apoptosis induced by pharmacological inhibition of CK2. Ann NY Acad Sci. 2009;1171:591-599.
Wang G, Ahmad KA, Harris N, Ahmed K. Impact of protein kinase CK2 on inhibitor of apoptosis proteins in prostate cancer cells. Mol & Cell Biochem. 2008;316:91-97.
Ahmad KA, Wang G, Unger G, Slaton J, and Ahmed K. Protein kinase CK2 - a key suppressor of apoptosis. Advan Enzyme Regul. 2008;48:179-187.
Ahmad KA, Harris N, Lindvall H, Johnson AD, Wang G, Ahmed K. Protein kinase CK2 modulates Resveratrol and EGCG induced apoptosis in prostate cancer cells. Molecular Cancer Therapeutics. 2007;6(3):1006-1012.
Ahmad KA, Wang G, Ahmed K. Intra-cellular hydrogen peroxide production is an upstream event in apoptosis induced by downregulation of casein kinase 2 in prostate cancer cells. Molecular Cancer Research. 2006;4:331-338.
Wang G, Ahmad KA, Khalil Ahmed K. Role of protein kinase CK2 in regulation of TRAIL induced Apoptosis in prostate cancer cells. Cancer Research. 2006;66:2242-2249.
Ahmad KA, Wang G, Unger, G, Slaton J, Ahmed K. Targeting CK2 for cancer therapy. Anticancer Drugs. 2005;16:1037-1043.
Ahmad KA, Clément MV, Hanif IM, Pervaiz S. Resveratrol inhibits drug-induced apoptosis in human leukemia cells by creating an intracellular milieu non-permissive for death execution. Cancer Research. 2004;64:1452-1459.
Ahmad, KA, Malik, FY, Hulbert, JR. Student preferences for case studies: enhanced learning in a human physiology course. Medical Science Educator. 2012;22(3):117-120.
Hanson L, Burns Ryan K, Ahmad, KA. Designing clinical pamphlets in a physiology course facilitates learning in chiropractic students. JIAMSE (Medical Science Educator). 2010;20(2):120-123.
Books and book chapters:
Ahmad KA. Hyperparathyroidism/nephrolithiasis. In: Beirman R, Case Studies in Differential Diagnosis for the Physical and Manipulative Therapies. Sydney, Australia: Elsevier; 2011.
Ahmad KA. Case Studies. In: Frucht, S. Visual AP Primal Pictures. 1st ed. bluedoor publishing; Sept. 2011.
Ahmad KA. Case Studies. In: Frucht, S. Visual Anatomy and Physiology I. 1st ed. bluedoor publishing; July 2011.
Wiles M, Williams J, Ahmad KA. Essentials of Dermatology for Chiropractors. 1st ed. Sudbury, MA: Jones and Bartlett Learning; 2010.
Ahmad, KA. Tumor cell response to drug induced apoptosis is a function of intra-cellular redox status. [doctoral thesis] Singapore: National University of Singapore; 2005.
Ahmad KA. Recent advances in the diagnosis and control of cutaneous tuberculosis. [master's thesis]. London, UK: University of London; 1998.