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Biochemistry I - 11010



Purification Table Exercise

Statistics

Exam 1
Exam 2
Exam 3
Final Exam

 

 

Verena Van Fleet , PhD
Winter 2007
Phone Number: (952) 888 7774 Ext. 289
Office Hours:
Mon, Tue, Wed: noon-1 p.m. or by appointment
5
90
4
2

The functional chemistry of the human body, integrating topics in cellular physiology with biochemistry; buffers, proteins, enzymes, carbohydrates, lipids, nucleic acids, and intermediary metabolism. Lab includes methods of separation and identification of biochemical constituents.

Please select from the list on the right.

The Institution-wide learning goals define the common ground that unites the programs within the university. They are purposefully broad so that the various colleges and schools can continue to develop their unique identities through varying ways in which the goals are met.

  1. Effective Communication
    Graduates will demonstrate effective verbal, non-verbal, and written communication skills in a wide variety of contexts, including collaborative activities.
  2. Self Directed and Lifelong Learning
    Graduates will be aware of the limits of one’s personal knowledge and experience and have an intellectual interest in scholarly and creative endeavors. Graduates will actively set appropriate learning goals, pursue them, and apply the knowledge gained.
  3. Ethical Reasoning
    Graduates will demonstrate a willingness to recognize the values of others while maintaining one’s own integrity, and act ethically and professionally in all endeavors.
  4. Individuals, Communities and Cultures
    Graduates will demonstrate awareness and sensitivity to the cultural and health practices of individuals and communities. Graduates will be able to identify appropriate health related resources.
  5. Service to the Community
    Graduates will understand and value the benefits of service to the community.
  6. Influence of Mind, Body and Spirit on Health
    Graduates will recognize the inter-relationship of the mind, body and spirit and the influence of extrinsic factors on an individual’s health.
  7. Critical Thought and Knowledge Acquisition
    Graduates will acquire, appraise and apply scientific information. Graduates will contextually organize and synthesize relevant information to address an issue or problem.
  8. Competence in one's Discipline
    Graduates will demonstrate competence of appropriate depth and scope for one's discipline.

Course Objectives
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  • FOUNDATIONS IN BIOCHEMISTRY
    - Chemical Foundations
  • STRUCTURE AND CATALYSIS
    - Amino Acids / Proteins
    --> Enzyme Kinetics
    - Carbohydrates
    - Lipids
    --> Vitamins
    --> Membranes
    - Nucleotides / Nucleic Acids
  • BIOENERGETICS AND METABOLISM
    - Cellular Respiration
  • INFORMATION PATHWAYS
    - From DNA to Proteins
Materials
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A. Required Text(s):
  • Nelson, D.L. and Cox, M.M., Lehninger Principles of Biochemistry, 4th Ed. (2005), ISBN: 0-7167-4339-6
    or
  • Nelson, D.L. and Cox, M.M., Lehninger Principles of Biochemistry, 3rd Ed. (2000) ISBN: 1-57259-931-6

You will need a text to clarify and supplement the material covered in lecture. I recommend Lehninger Principles of Biochemistry; it covers all areas of biochemistry and is also the required text book of Biochemistry II.

  • Van Fleet, Biochemistry 1 Lecture Notes is available in the bookstore. It contains a collection of figures, tables and problems used in lecture.
  • Calculator - You will need a scientific calculator (one which will do logarithms and exponentials) for the first part of the lecture.

B. Recommended Text(s):
  • Murry, R.K., Granner, D.K., Mayes, P.A., and Rodwell, V.W., Harper's Biochemistry, 27th Ed. (2006) ISBN: 0-07-147885-x

If you feel you have some background and or aptitude in biochemistry the Harper's review text would be appropriate. It is more concise and covers topics related to health and disease.


C. Required Materials for Lab:
  • Richardson, J., Van Fleet, V., Biochemistry Laboratory Manual, This manual is available in the bookstore. You will need to bring it to each laboratory session including the first one.
  • Lab coat
  • Calculator - You will need a scientific calculator (one which will do logarithms and exponentials) throughout the term in the laboratory.
Assignments
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Two homework assignments
Attendance
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Students are strongly advised to attend all classes. Exams will be based on what is covered in class supported by the assigned chapters in the book. There will be no make-up quizzes. In each lab session you earn credits towards your final grade.
Grading Criteria
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Credit Distribution

3 Exams

45%
Final Exam

20%
5 Quizzes/Assignments 10%
Laboratory work 10%
Laboratory Final 15%

Three one hour exams will be given over the course of the trimester. The Final Exam is comprehensive. Exams will cover the material we have covered in lecture and material that I have explicitly told students to cover on their own. Exam questions will be 80-100% multiple choice and 0-20% essay questions.

There will be 4 short announced quizzes and two homework assignments that will cover the material presented since the previous quiz or exam (lowest score will be dropped).

Exams and Quizzes can be reviewed and grades appealed within two weeks of the date the scores were posted. After that the exams/quizzes will be shredded.

The Laboratory requirements will be discussed in detail during the introductory lab. In a nutshell, all pre-lab and lab report assignments amount to 700 pts. For every late submission 15 pts will be deducted. In addition, there will be a lab final that is typically scheduled on the same day as the class final.

Exam Schedule

  • Exam 1 - January 29, 2007
  • Exam 2 - February 26, 2007
  • Exam 3 - March 19, 2007
  • Final Exam - to be announced (April 2-12, 2007)

Guaranteed grades are as follows:

A = 90 - 100%
B = 80 - 89.9%
C = 70 - 79.9%
D = 63 - 69.9%
F = <63%
Course Competencies
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-
  1. COGNITIVE DOMAIN

    Enter text here.

    Conditions:
    Enter conditions here.

  2. PSYCHOMOTOR DOMAIN

    Enter text here.

  3. AFFECTIVE DOMAIN

    Enter text here.
Weekly Calendar of Learning Objectives
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Week

 

 

Topic

 

Lehninger

Chapter (pages)

3rd edition

 4th edition

Week 1

(01/01-01-05)

01/01 No Class! (New Year's Day)

New student orientation (special schedule)

Chemical Foundations: Assignent 1 (Due on 03/11)

 

 

 

3 (53-73)

 

 

 

1 (10-21)

Week 2

(01/08-01/12)

Course Outline

Ionization of Water

Weak Acids and Bases

ASSIGNMENT 1 due (03/11)

4 (82-101)

4 (101-107)

 

2 (47-65)

2 (65-70)

 

Week 3

(01/15-01/19)

01/15 No Class! (MLK Day)

Titrations / Buffers

QUIZ 1 (01/17)

AMINO ACIDS; pI

 

 

 

5 (115-126)

 

 

 

3 (75-85)

Week 4

(01/22-01/26)

Peptides and Proteins

3D Structure of Proteins

5 (126-145)

6 (159-191, 196)

3 (85-106)

4 (116-147, 150)

Week 5
01/29-02/02)
No labs! (Homecoming)

EXAM 1 (01/29)

Protein Function: Myoglobin/

Hemoglobin

 

7 (203-208)


7 (208-221)

 

5 (152-161)


5 (162-174)

Week 6

(02/05-02/09)

ENZYMES (Introduction)

Enzyme Kinetics

Inhibitors

8 (243-246)

8 (257-265)

8 (265-269)

6 (190-193)

6 (202-174)

6 (209-213)

Week 7

(02/12-02/16)

QUIZ 2 (02/12)

Regulatory Enzymes

Blood Clotting

CARBOHYDTRATES: Monosaccharides

 

8 (278-289)

 

9 (293-301)

 

6 (225-233)

 

7 (238-245)

Week 8

(02/19-02/23)

02/19 No Class! (Presidents's Day)

Glycosidic Bond; Disaccharides/ Polysaccharides

Glycoconjugates; Informational Sugars

ASSIGNMENT 2 due (02/22)


9 (301-310)


9 (Selected Examples)


7 (245-253)


7 (Selected Examples)

Week 9

(02/26-03/02)

EXAM 2 (02/26)

LIPIDS: Fatty Acids / Storage Lipids

Membrane Lipids; Signals

 

11 (363-368)


11 (369-383)

 

10 (343-348)


10 (348-363)

Week 10

(03/05-03/09)

Vitamins

Biological Membranes

QUIZ 3 (03/06)

BIOENERGETICS AND METABOLISM


Overview Cellular Respiration

See Index

12 (389-404, 408-skim)

 

III (485-489); 14 (490-494)


Handout

See Index

11 (369-380) 11.3 (skim)

 

II (481-488); 13 (489-491)


Handout

Week 11

(03/12-03/16)

Glycolysis: Preparatory Phase

Glycolysis: Payoff Phase

QUIZ 4 (03/13)

Production of Acetyl-CoA

Citric Acid Cycle

15 (527-535)

15 (535-540)

 

16 (567-571)

16 (571-586)

14 (521-529)

14 (529-534)

 

16 (601-606)

16 (606-620)

Week 12

(03/19-03/23)

EXAM 3 (03/19)

Electron Transport Chain /

Oxidative Phosphorylation

19 (659-686)

 

19 (690-716)

 

Week 13

(03/26-03/30)

NUCLEOTIDES AND NUCLEIC ACIDS


Mutations

Genes and Chromosomes


DNA Replication


Transcription / RNA Viruses


Genetic Code / Translation

10 (325-332, 332-340, 348-358)

10 (348-351)

24 (905-917, 923-928)

25 (931-937, 949-959)

26 (Selected Topics)

27 (1020-1068)

8 (273-279, 82-286, 293-302)


8.3 (293-295)

24 (923-932), 938-945)

25 (950-954, 966-978)

26 (Selected Topics)

27 (1034-1067)

Week 14/15

(04/02-04/12)

 FINAL EXAMS  
Please Note
This schedule of lecture and lab topics and quizzes and exams may be changed during the course of the trimester as circumstances require. Whenever possible, such changes will be announced in class before the date and time in question. You are responsible for anything that transpires during lectures and labs, even when you are unable to attend. In the event that you miss a class session, make sure you check with a classmate about any announcements or schedule changes which may have been made. Makeup exams are allowed only according to the policies described in the current student handbook, which is available in the Student Affairs office.

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Last updated: 8 January, 2007

 

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