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Pathology I - #17030


 

 
Dr. Norman Horns
3.0
45
3.0
0.0

Students will study basic disease mechanisms and processes.
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    Graduates will recognize the inter-relationship of the mind, body and spirit and the influence of extrinsic factors on an individual’s health.
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    Graduates will acquire, appraise and apply scientific information. Graduates will contextually organize and synthesize relevant information to address an issue or problem.
  8. Competence in one's Discipline
    Graduates will demonstrate competence of appropriate depth and scope for one's discipline.

Course Objectives
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To provide the students with a working understanding of the basic mechanisms of disease. This understanding will form the basis for study of organ system pathology in the subsequent Pathology II course. The knowledge gained in both courses will enhance students' clinical skills in evaluating, diagnosing, and treating (either primarily or by referral) various diseases. The approach in Pathology I will be at a molecular, ultra structural, cellular, and tissue level.
Materials
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A. Required Text(s):
  1. Kumar/Robbins & Cotran, Pathologic Basis of Disease 7th ed'05, Saunders; or Kumar/Robbins, Basic Pathology 7th ed '03, Saunders
  2. Written course notes
  3. Handouts

B. Recommended Text(s):
None
C. Required Materials for Lab:
None
Assignments
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A. --
Attendance
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Attendance at lectures is expected since these will augment material presented in the notes and textbook.

This schedule may be subject to change during the course of the trimester. If that becomes necessary, changes will be announced in class as early as possible. In case of an absence, it is the student's responsibility to check with the instructor or classmates regarding announced alteration to the normal schedule.

Makeup quizzes or exams are given only with an excused absence. The usual fee will be charged, as outlined in the student handbook; or as advised by the instructor if there are extenuating circumstances being allowed.
Grading Criteria
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  1. The primary type of test questions will be a combination (in varying proportions) of: multiple choice and true/false
  2. The examinations will/may include material from the lecture notes, lectures, and text book.
    Test Dates and Points
  3. Tests are to be taken on the assigned day except for illness or other acceptable emergency interference. In case of an acceptable reason, tests may be taken early or late by arrangement with the instructor.
  4. A $30 fee will be charged where appropriate for early or late exams.
Exam 1 Wednesday, May 23 50-60 questions Covers material since the start of the course
Exam 2 Wednesday, June 13 50-60 questions Cover material since Exam 1
Exam 3

Wednesday, July 11

 50-60 questions Covers material since Exam 2
Exam 4

During Finals Week
July 30-August 3
August 6-August 9

 To be announced Content to be announced

Guaranteed grades are as follows:

A = 92-100%
B = 82-91%
C = 72-81%
D = 65-71%
F = below 65%
Course Competencies
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COGNITIVE DOMAIN


A. For the following topics, the student will attain knowledge of:

  1. appropriate underlying molecular biologic phenomena of basic disease processes.
  2. pathophysiologic and pathologic manifestations of basic disease processes.
  3. how these pathologic processes alter normal cellular, tissue, and organ function.
  4. the resulting clinical manifestations presented in patients from pathologic processes.

B. Topic categories presented in the course:

  1. Cellular reactions to injury and stress.
  2. Mechanisms and causes of cellular injury.
  3. Types of inflammation

    a. molecular mediators and components of inflammation
    b. types of inflammatory cells and different functions
    c. role of blood vessels in inflammation
  4. Immunopathology

    a. components and physiology of the immune system; cellular and humoral immunity
    b. the four types of hypersensitive reactions and the mechanisms by which they produce tissue injury
    c. immunologic basis of organ and tissue transplantation reactions
    d. immunodeficiency disease examples including HIV disease
    e. tuberculosis, an example of an infectious disease producing a delayed type of hypersensitivity response
    f. auto immune diseases
  5. Neoplasia (tumors)

    a. distinctive features of benign and malignant tumors
    b. basic types of carcinogens
  6. Developmental and genetic disorders

    a. abnormalities of morphogenesis
    b. common genetic disorders
  7. Hemodynamic disorders

    a. hemorrhage
    b. active and passive congestion
    c. edema
  8. Physical and Environmental Injuries

    a. chemical, common examples
    b. thermal
  9. Infectious Diseases

    a. viral
    b. bacterial infections discussed under organ pathology in Pathology II


Conditions:
--

PSYCHOMOTOR DOMAIN


--

AFFECTIVE DOMAIN


--
Weekly Calendar of Learning Objectives
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Week Dates Topics/Learning objectives
Week 1 May 2-3

Types of cellular responses to injury and stress. Mechanisms of cellular injury

Week 2 May 9-10 Inflammation, Inflammatory mediators
Week 3 May16-17 Complement System, Cellular morphologic components of inflammation
Week 4

May23-24

Basic types of immune responses. Types of antibodies, Humoral, Immunity
Week 5 May30-31 Cellular immunity, Antigen presenting cells, Band T cell activation, Type 1 and 2 Hypersensitivity
Week 6 June 6-7 Type 3 and 4 Hypersensitivity. Tissue and Organ Transplantation, Amyloidosis
Week 7 June 13-14 Immunodeficiency Disorders, HIV Disease
Week 8 June 20-21 HIV Disease, Tuberculosis, Autoimmune Disorders
Week 9 June 27-28

Neoplasia (Tumors), general concepts

Oncogenesis
Week 10 July 4-5

July 4th Holiday-No class
July 5th-Developmental Disorders, Genetic Syndromes
Week 11 July 11-12 Hemodynamic Disorders (including shock)
Week 12 July 18-19 Enviroment Injuries, Viral infections
Week 13 July 25-26 Viral Infections
Week 14 July 30-Aug 3 Final Exams
Week 15 Aug 6-9 Final Exams
Please Note
This schedule of lecture and lab topics and quizzes and exams may be changed during the course of the trimester as circumstances require. Whenever possible, such changes will be announced in class before the date and time in question. You are responsible for anything that transpires during lectures and labs, even when you are unable to attend. In the event that you miss a class session, make sure you check with a classmate about any announcements or schedule changes which may have been made. Makeup exams are allowed only according to the policies described in the current student handbook, which is available in the Student Affairs office.
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Last updated: 10 April, 2007
 

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