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Neuroscience I:
Peripheral Nervous System - #12120



 

 

Mary M. Tuchscherer, DC, PhD
4.0
4.0
60.0
0.0
In-depth study of the organization of the nervous system followed by a detailed study of neurophysiology, including receptor pharmacology; spinal nerves, with major emphasis on visceral and somatic afferent and efferent PNS pathways; reflex arcs; common segmental innervations, and dematomes.
Please select from the list on the right.

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  1. Effective Communication
    Graduates will demonstrate effective verbal, non-verbal, and written communication skills in a wide variety of contexts, including collaborative activities.
  2. Self Directed and Lifelong Learning
    Graduates will be aware of the limits of one’s personal knowledge and experience and have an intellectual interest in scholarly and creative endeavors. Graduates will actively set appropriate learning goals, pursue them, and apply the knowledge gained.
  3. Ethical Reasoning
    Graduates will demonstrate a willingness to recognize the values of others while maintaining one’s own integrity, and act ethically and professionally in all endeavors.
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    Graduates will demonstrate awareness and sensitivity to the cultural and health practices of individuals and communities. Graduates will be able to identify appropriate health related resources.
  5. Service to the Community
    Graduates will understand and value the benefits of service to the community.
  6. Influence of Mind, Body and Spirit on Health
    Graduates will recognize the inter-relationship of the mind, body and spirit and the influence of extrinsic factors on an individual’s health.
  7. Critical Thought and Knowledge Acquisition
    Graduates will acquire, appraise and apply scientific information. Graduates will contextually organize and synthesize relevant information to address an issue or problem.
  8. Competence in one's Discipline
    Graduates will demonstrate competence of appropriate depth and scope for one's discipline.

Course Objectives

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  1. Introduction & Review of the Typical Spinal Nerve & Histology of the Nervous System.
    The student is expected to demonstrate, in written format, a thorough understanding of the functional components associated with each portion of the typical spinal nerve. This information will be tested on each exam given in the course, including the final exam. The student will also review and demonstrate recognition and functional significance of the histology of the nervous system, particularly as it relates to the peripheral nervous system.
  2. General Neurophysiology
    Neurophysiology will be covered extensively, and the student is expected to demonstrate, in written format, a thorough understanding of the generation and maintenance of resting potential, depolarization, action potential, hyperpolarization, generator potentials, EPSPs, and IPSPs; concepts of summation, refractory periods, impulse propogation, and second messenger systems.
  3. General Neuropharmacology
    An introduction to neuropharmacology is given, stressing events at the chemical synapse. The student is expected to demonstrate, in written format, an understanding of the inclusion/exclusion criteria for identifying a substance as a neurotransmitter substance; details of activity, receptor binding, and specific agonists and antagonists, specifically the following neurotransmitters / neuromodulators: actylcholine, enkephalin, GABA/glycine, dopamine, serotonin, norepinephine/epinephrine, substance P, glutamate, and aspartate.
  4. Receptor Physiology
    General receptor physiology is discussed with reference to neuropharamcology and neurophysiology. The three main types of receptors are discussed in some detail, and the student is expected to demonstrate, in written format, an understanding of these concepts: passive (non- gated) ion channels, ligand-dependent ion channels, and voltage-dependent ion channels. Additionally, second messenger activity as regards ion channel physiology is also discussed, and expected to be understood.
  5. Spinal Reflexes and the Motor Systems
    Motor systems are introduced, conscious motor activity and control of skeletal muscle contraction is the concentration. Upper and lower motor neuron concepts are discussed, and the clinical concepts of flaccid and spastic paralyses introduced. Reflex patterns are discussed in detail and are expected to be understood in detail. The student is expected to demonstrate in written format, an understanding of the information above, as well as the concepts of fast and slow muscle. This unit also continues the discussion of proprioception, muscle spindle activity, and Golgi tendon organ function. These concepts will also be tested in written format.
  6. Visceral Afferents and the Autonomic Nervous Sytem.
    Throughout the course, the relationship between the autonomic nervous system and the somatic motor nervous system will be stressed. The visceral and somatic afferents will be discussed in several units and their properties compared. The last four units of the course will carefully describe the innervation of each organ system specifically. The segmental origin and peripheral course of the autonomic input to these systems will be thoroughly described. It is expected that the student pay close attention to autonomic system examples given throughout the course, and have a solid background in autonomic patterns of innervation through the functional component discussions and testing before beginning these final units. The final exam will test primarily the student's ability to compare and contrast somatic and visceral patterns of input in terms of neurophysiology, neuropharmacology, and receptor physiology as well as neuroanatomy.
Materials
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A. Required Text(s):
  • Principles of Neural Science (Fourth Edition). Kandel, Schwartz, and Jessell. Elsevier Publishing.
  • PNS Notes M.M. Tuchscherer, DC, PhD
    B. Recommended Text(s):
  • The Human Nervous System Barr and Kiernan. Harper and Row.
  • The Brain. An Introduction to Neuroscience. Thompson. Freeman Press.
  • The Peripheral Nervous System. Mathers. Mobsy Publishing.
  • The Biochemical Basis of Neuropharmacology Cooper, Bloom, and Roth.
  • Autonomic Functions in Human Physiology. Thews and Vaupel. Springer-Verlag.
    C. Required Materials for Lab:
    None
  • Assignments
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    As indicated on the Weekly Calendar of Learning Objectives
    Attendance
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    Attendance is required
    Grading Criteria
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    • Exams and quizzes will be taken on the dates as scheduled within the first two weeks of class, unless mutual agreement to re-schedule is met through class vote (simple majority, when the course director approves). Though it is understood that weddings or religious holidays are examples of excused absences, zero's will be entered in the event of un-excused absence. Make-up exams, when considered appropriate, are given according to the student handbook requirements. Students are expected to read the handbook, be aware of the policies and adhere to them.

    • There will be 3 written exams (each worth 100 points) and 1 written final (worth 200 points). Ten percent (10%) of the grade will be based on six weekly quizzes each worth ten points. The third exam is typically take-home format. Details will be given in class.

    • A grade of "A" requires 90% of the points given; "B's" require 80% of the points given; "C's" require 70% of the points given; "D's" require NO LESS than 65% of the points given.

    • Examinations may include material that has not been thoroughly discussed in class. You are responsible for all readings assigned. No more than 10% of any exam would contain independent reading material.

    • Regrading of quizzes and exams must be accomplished within one week of initial grading. None will be accepted after this period.

    • The syllabus is subject to change to within two weeks notice of the final. This means grading scales may change (though only downward); additional assignments may be made and other modifications may occur as the professor deems necessary. Every effort will be made to keep the student's best interest in mind.

    • I expect students to work hard, appear in class on time, and afford myself and your peers the appropriate level of respect. I will be equally respectful of you.

    • As you know, my teaching style allows great latitude for creative use of class time, providing the class is mature in its handling of this responsibility. I expect high standards of integrity, as I'm sure you expect these of me. Demonstration of inability to maintain a professional attitude required of Doctors of Chiropractic will not be tolerated. Up to 30 points (5% of your grade) may be subtracted from your grade based on professionalism in class. The course director makes the final decision regarding the disposition of these points.

    • Weekly quizzes: Each week you will receive assignments regarding the worksheets on "Quiz Info Pages" detailing the segmental organization of the PNS. You will receive only minimal instruction regarding these worksheets, as they are largely self explanatory. Six weekly quizzes will be given. These quizzes will account for 10% of your final grade. NO MAKE-UPS will be allowed, except in cases of emergency. You will be expected to memorize the segmental origin(s) of each named nerve assigned, the muscle(s) to which the nerves of segments project and the actions of the muscles named. You will be responsible for the segmental origins as they are given IN THIS SYLLABUS!!! I have tried to correlate these segmental origins with your anatomy and NMS classes. If other discrepancies arise, please discuss it with me OUTSIDE of class time, and I will make a general announcement regarding any changes. It will be expected that you will have this information committed to LONG TERM memory following this class. THE QUIZ INFORMATION WILL NOT APPEAR ON THE MAJOR EXAMS.

    Guaranteed grades are as follows:

    A = 90-100%
    B = 80-89.5%
    C = 70-79.5%
    D = 65-69.5%
    F = <65.5%
    Course Competencies
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    -A. The student will be able to describe the resting potential, passive ion channels, and the importance of the sodium potassium pump.

    -B. The student will be able to describe the action potential in detail. The importance of gated ion channels, G-proteins and concepts of summation will be demonstrated through didatic questioning.

    -C. To be continued.

    COGNITIVE DOMAIN


    -

    Conditions:

    Clinical Condition Etiol. & Epidem. Patho-phys Nat.History & course Exam & Dx RX/Mgmt
    Acoustic Neuroma 1 1 1 1,2,3,6 6
    Auditory Processing Disorder 1 1 1 1 1
    Alcoholism 2 2 2 1,2,3,7 3,5
    ALS (Lou Gehrig's) 3 3 3 1,2,3,6 4,5,6,7
    Alzheimer's Disease 2 2 2 1,2,3,6 3,4,5,6,7
    Bell's Palsy 3 3 3 1,2,3,4 1,2,3,4,5,6,7
    BPPV 1 1 1 1,2,3 1,6,7
    Carpal Tunnel Sy. 3 3 3 1,2,3,4,7 1,2,3,4,5,6
    Cerebral Palsy 2 2 2 1,2,3,6, 4,5,6
    Cervicogenic Vertigo 2 2 2 1,2,3,4 1,5
    Cubital Tunnel Sy. 3 3 3 1,2,3,4,7 1,4
    Diabetes Mellitus 2 2 2 1,2,3,5 1,3,4,5,6
    Disc Herniation - C/S 3 3 3 1,2,3,4,6 1,2,4,5,6,7
    Disc Herniation - L/S 2 2 2 1,2,3,4,6 1,2,4,5,6,7,
    Disc Herniation - T/S 2 2 2 1,2,3,4,6 1,2,4,5,6,7
    Encephalitis 1 1 1 1,2,3,5,6 6
    Freidreich's Ataxia 1 1 1 1,3 0
    Genitofem. N. Entrap. 2 2 2 1,2,3,4,7 1,4
    Guillain-Barre Sy. 1 1 1 1,2,3,5 6
    Headache - Cluster 2 2 2 1,2,3,4,6 1,2,3,4,5,6
    Headache - Migraine 3 3 3 1,2,3,4,5,6 1,2,3,4,5,6,7
    Headache - Rebound 1 1 1 1,2,3,4,5 1,2,3,5
    Headache - Tension 2 2 2 1,2,3,4 1,2,3,4,5,6
    Herpes Zoster 2 2 2 1,2,3,4 1,2,6,7
    Intracranial Masses 2 2 2 1,2,3,5,6 6
    Labyrinthitis 1 1 1 1,2,3 1,6,7
    Maigne's Syndrome 1 1 1 1,2,3,4,7 1,4
    Meniere's Disease 2 2 2 1,2,3 1,3,5,6,7
    Meningitis 2 2 2 1,2,3,5,6 6
    Meralgia Paresthetica 2 2 2 1,2,3,4,7 1,4
    Multiple Sclerosis 3 3 3 1,2,3,4,5,6 1,2,3,4,5,6,7
    Muscular Dystrophy 2 2 2 1,2,3,5,6,7 1,4,5,6
    Myasthenia Gravis 2 2 2 1,2,3,5,6,7 1,4,5,6
    Myelopathy 3 3 3 1,2,3,4,5,6 1,2,4,5,6
    Neurofibromatosis 1 1 1 1,3 0
    Optic Neuritis 2 2 2 1,2,3,5,6 6
    Parkinson's Disease 3 3 3 1,2,3,4,5,6 1,2,3,4,5,6,7
    Peroneal Tunnel Sy. 1 1 1 1,2,3,4,7 1,4
    Piriformis Syndrome 2 2 2 1,2,3,4,7 1,4
    Post-Concussive Sy. 3 3 3 1,2,3,4,6,7 1,2,3,4,5,6,7
    Pronator Teres Sy. 2 2 2 1,2,3,4,7 1,4
    Radiculopathy - C/S 3 3 3 1,2,3,4,5,6 1,2,4,5,6
    Radiculopathy - L/S 2 2 2 1,2,3,4,5,6 1,2,4,5,6
    RSD/CRPS (Causalgia) 3 3 3 1,2,3,4,6,7 1,2,3,4,5,6,7
    Schizophrenia 1 1 1 1,2 6,7
    Seizures-Epileptic 2 2 2 1,2,3,4,5,6,7 1,3,4,5,6,7
    Seizures-Nonepileptic 2 2 2 1,2,3,6,7 6
    Stroke 3 3 3 1,2,3,4,5,6 1,2,3,4,5,6,7
    Supinator Sy. 2 2 2 1,2,3,4,7 1,4
    Syringomyelia 2 2 2 1,2,3,6 6
    Tarsal Tunnel Sy. 3 3 3 1,2,3,4,7 1,4,6
    Thoracic Outlet Sy. 2 2 2 1,2,3,4,7 1,4,6
    Thyroid Disorders 2 2 2 1,2,3,5 1,3,4,5,6
    TIA 3 3 3 1,2,3,4,5,6 1,2,3,4,5,6,7
    Tourette's Syndrome 1 1 1 1,2,3,6 6
    Trigeminal Neuralgia 3 3 3 1,2,3,4,6 1,2,3,4,5,6,7
    Ulnar Tunnel Sy. 3 3 3 1,2,3,4,7 1,4
    Vestibular Neuritis 2 2 2 1,2,3 1,6,7
    Whiplash Injuries 2 2 2 1,2,3,4,6 1,2,4,6


    PSYCHOMOTOR DOMAIN


    -A. Students will be able to demonstrate simple muscle tests associated with the brachial and lumbosacral plexus nerves. These tests will be taught during class time and the student will practice them on their own time. The testing of this knowledge will take place mainly in the weekly quizes.

    AFFECTIVE DOMAIN


    -During the lecture portion of the course the student is expected to use respectful, professional language and behavior while discussing a wide variety of topics. It is the goal of the professor to stimulate lively discussion and entertain questions during the lecture period. The student is expected to use this opportunity to practice professional language and attitudes.
    Weekly Calendar of Learning Objectives
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    Week Dates Topics/Learning objectives
    Week 1

     

    Review of the Typical Spinal Nerve
    Reading:
    Week 2

     

    Review of General Histo; Injury of Nerve Cells; Methods of Research
    Reading: Kandel: 18-31; 34-47, 258-268
    QUIZ 1: January 8, 2007 T-Z writes quiz.
    Week 3

    General Neurophysiology
    Action Potentials, Ion Channels.
    Importance of Ca++. Pre- and Postsynaptic Potentials, slow Postsynaptic Potentials.
    Reading: Kandel: 81-94, 95-103, 104-118; appendix A: 1033
    QUIZ 2: January 22, 2007 A-D writes quiz.

    Week 4 Events at the Synapse
    Second Messengers,
    Slow synaptic potentials
    Reading: Kandel: 120-133, 135-148, 194-209
    EXAM I: UNITS 0-5, TBA
    Week 5 Pharmacologic agents used in studying neural functions. Neurotransmitters and their receptors.
    Reading: Kandel: 173-192, 213-224, 235-242, 858-867, 869-882
    QUIZ 3: January 29, 2007 O-S writes quiz.
    Week 6 Pharmacologic agents used in studying neural functions. Neurotransmitters and their receptors.
    Reading: Thompson: 337-354; Kandel: 173-192, 213-224, 235-242, 858-867, 869-882
    QUIZ 4: February 5, 2007, E-H writes quiz.
    Week 7

     

    General Sensation
    Reading: Kandel: 329-339, 341-352, Briefly-353-365, 367-383;
    EXAM II: UNITS 5-7, TBA
    Week 8 Motor systems, reflex Arcs
    Reading: Kandel: 533-624, especially 564-579
    QUIZ 5: February 12, 2007 I-N writes quiz
    Week 9

     

    Autonomics Introduction
    Reading: Kandel: 761-768
    QUIZ 6: February 26, 2007

    Week 10 EXAM III: TBA
    Week 11 Action on the Digestive System
    Reading: Units 12-13
    Week 12 Micturition and Defecation
    Genital reflexes
    Reading: Units 13-14
    Week 13 Review
    Week 14 FINALS WEEK- FINAL EXAM COVERS PRIMARILY AUTONOMICS
    Be reminded this exam is worth 200 points
    Week 15 FINALS WEEK
    Please Note
    This schedule of lecture and lab topics and quizzes and exams may be changed during the course of the trimester as circumstances require. Whenever possible, such changes will be announced in class before the date and time in question. You are responsible for anything that transpires during lectures and labs, even when you are unable to attend. In the event that you miss a class session, make sure you check with a classmate about any announcements or schedule changes which may have been made. Makeup exams are allowed only according to the policies described in the current student handbook, which is available in the Student Affairs office.
    Maintained by Northwestern College of Chiropractic
    Last updated: 10 Jan 2007
     

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