Lisa Oppegard, PhD

Publications

• The C7-aminomethylpyrrolidine group rescues the activity of a thio-fluoroquinolone, SCIENTIFIC PUBLICATIONS Lentz, S. R.C., Chheda, P.R., Oppegard, L.M., Towle, T.R., Kerns, R.J., Hiasa, H., 2019
• Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity., Oppegard, L.M., Delgado, J.L., Kulkarni, C.A., Towle, T.R., Hart, D.E., Williams, B.P., Lentz, S.R.C., Norris, B.J., Flory, C.M., Schumacher, R.J., Murry, D.J., Kerns, R.J., Hiasa, H., 2018
• Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: probing for binding contact with the active site tyrosine of gyrase., Towle, T.R., Kulkarni, C.A., Oppegard, L.M., Williams, B.P., Picha, T.A., Hiasa, H., Kerns, R.J., 2018
• Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones, Malik, M., Mustaev, A., Schwanz, H., Gan, L., Shah, N., Oppegard, L., de Souza, E., Hiasa, H., Zhao, X, Kerns, R., Drlica, K., 2016
• Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg(2+) to the second metal binding site, Oppegard, L.M., Schwanz, H.A., Towle, T.R., Kerns, R.J., Hiasa, H., 2016
• Fluoroquinolone-gyrase-DNA complexes: two modes or drug binding, Mustaev, M., Malik, M., Zhao, X., Kurepina, N., Oppegard, L.M., Hiasa, H., Marks, K.R., Kerns, R.J., Berger, J.M. Drlica, K., 2014
• Flavone-based analogues inspired by the natural product simocyclinone D8 as DNA gyrase inhibitors, Verghese, J., Nguyen, T., Oppegard, L.M., Seivert, L.M., Hiasa, H., Ellis, K.C., 2013
• Selective inhibition of bacterial and human topoisomerase by N-arylacyl O-sulfonated aminoglycoside derivatives, Fenner, A.M., Oppegard, L.M., Hiasa H., Kerns, R.J., 2013
• Solphenazines A-F, Glycosylated Phenazines from Streptomyces sp, Rusman Y., Oppegard, L.M., Hiasa H., Gelbmann, C., Salomon C.E., 2013
• Inhibition of human topoisomerases I and II by simocyclinone D8, Oppegard, L.M., Nguyen T., Ellis K.C., Hiasa H., 2012
• Comparison of in vitro activities of fluoroquinolone-like 2,4- and 1,3-diones. Antimicrob. Agents Chemother, Oppegard L.M., Streck K.R., Rosen J.D., Schwanz H.A., Drlica K., Kerns R.J., Hiasa H., 2010
• In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus, Oppegard, L.M., Hamann, B.L., Streck, K.R., Ellis K.C., Fiedler H.-P., Khodursky A. B., Hiasa H., 2009
• Anti-proliferative effects of simocyclinone D8 (SD8), a novel inhibitor of topoisomerase II, Sadiq A.A., Patel M.R., Jacobson B.A., Escobedo M., Ellis K., Oppegard L.M., Hiasa H., Kratzke R.A., 2010
• Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II, Oppegard L.M., Ougolkov A.V., Luchini D.N., Schoon R.A., Goodell J.R., Kaur H., Billadeau D.D., Ferguson D.M., Hiasa H., 2009
• Cis-acting elements stimulating kinetoplast guide RNA-directed editing, Oppegard L.M., Hillestad M., McCarthy R.T, Pai R.D., Connell G.J., 2003
• Sequence and structural requirements for optimal-guide RNA-directed insertional editing within Leishmania tarentolae, Pai R.D., Oppegard L.M., Connell G.J., 2003
• Direct visualization of RNA editing within a Leishmania tarentolae extract, Oppegard L.M., Connell G.J., 2002
• A mRNA determinant of gRNA-directed kinetoplast editing, Kabb A.L., Oppegard L.M., McKenzie B.A., Connell G.J., 2001
• Activation of guide RNA-directed editing of a cytochrome b mRNA, Oppegard L.M., Kabb A.L., Connell G.J., 2000
• A cis-acting A-U sequence element induces kinetoplastid U-insertions, Brown L.M., Burbach B.J., McKenzie B.A., Connell G.J., 1999
• Cell cycle regulation of RPA transcript levels in the trypanosomatid Crithidia fasciculata, Brown L.M., Ray D.S., 1997
• Periodic expression of nuclear and mitochondrial DNA replication genes during the trypanosomatid cell cycle, Pasion S.G., Brown G.W., Brown L.M., Ray D.S. , 1994
• The Crithidia fasciculata CRK gene encodes a novel cdc2-related protein containing large inserts between highly conserved domains, Brown L., Hines J.C., Ray D.S., 1992